1-Substituted-2-(2-pyridinyl)ethanone N-oxides
AssigneeWarner-Lambert Company
InventorsDavid T. Connor, Patricia A. Young, Maximilian VON Strandtmann
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Abstract
1-Substituted-2-(2-pyridinyl)ethanone N-oxides having the formula I or II: ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 and R.sub.3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, or benzyloxy; R.sub.4 is halogen, hydroxy, lower alkyl, lower alkoxy, benzyloxy, ortho-amino, ortho-lower alkylamino, ortho-alkanoylamino or ortho-benzoylamino; and R.sub.5 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or benzyloxy; the pharmaceutically acceptable acid addition salts thereof, and a process for the preparation thereof, are described. The compounds of this invention are useful for the treatment of allergic conditions and for the treatment of hyperacidity.
Claims24
A compound of the formula II:
- ##STR40## wherein R.sub.1 is hydrogen or lower alkyl;
- R.sub.2 and R.sub.3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or benzyloxy;
- and R.sub.5 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or benzyloxy;
- and the pharmaceutically acceptable acid addition salts thereof.
A compound which is 1-(2-methoxyphenyl)-2-(2-pyridinyl)ethanone N-oxide.
A compound which is 1-[2-(methylamino)phenyl]-2-(2-pyridinyl)ethanone N-oxide.
A compound which is 1-[2-aminophenyl]-2-(2-pyridinyl)ethanone N-oxide.
A compound which is N-[2-(2-pyridinylacetyl)phenyl]benzamide N-oxide.
A compound which is 1-(2,3-dimethoxyphenyl)-2-(2-pyridinyl)ethanone N-oxide.
A compound which is 1-(5-bromo-2-methoxyphenyl)-2-(2-pyridinyl)ethanone N-oxide.
A compound which is 1-[2-(phenylmethoxy)phenyl]-2-(2-pyridinyl)ethanone N-oxide.
A compound which is 1-[5-chloro-2-(methylamino)phenyl]-2-(2-pyridinyl)ethanone N-oxide.
A compound which is 1-(2-methoxy-5-methylphenyl)-2-(2-pyridinyl)ethanone N-oxide.
A compound which is 1-(2-hydroxyphenyl)-2-(2-pyridinyl)ethanone N-oxide.
A compound which is 1-(2-methoxyphenyl)-2-(6-methyl-2-pyridinyl)ethanone N-oxide.
.alpha.-(2-Pyridinyl)-2-pyridineethenamine 1-oxide.
A compound which is 1,2-(N-oxide)-di(2-pyridinyl)ethanone.
A compound which is 1-(4-chlorophenyl)-2-(2-pyridinyl)ethanone N-oxide.
A compound which is 1-[5-chloro-2-methoxyphenyl]-2-(2-pyridinyl)ethanone N-oxide.
A compound which is 1-(3,4,5-trimethoxyphenyl)-2-(2-pyridinyl)ethanone N-oxide.
A compound which is 1-(4-methoxyphenyl)-2-(2-pyridinyl)ethanone N-oxide.
A compound which is 1-(4-fluorophenyl)-2-(2-pyridinyl)ethanone N-oxide.
A compound which is 1-(3-methoxyphenyl)-2-(2-pyridinyl)ethanone N-oxide hydrobromide.
A method for treating hyperacidity in mammals in need of such treatment which comprises the administration of an effective amount of the compound of the formula I or II:
- ##STR41## wherein R.sub.1 is hydrogen or lower alkyl;
- R.sub.2 and R.sub.3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or benzyloxy;
- R.sub.11 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, benzyloxy, ortho-amino, ortho-lower alkylamino, ortho-alkanoylamino or ortho-benzoylamino;
- and R.sub.5 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, benzyloxy, and the pharmaceutically acceptable acid addition salts thereof.
Dependencies are inferred from the claim text.