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US 4,056,562 AGranted
3,5-Bisoxygenated 2-(.omega.-halo-3-oxygenated-1-alkenyl)-cyclopentane-1-heptanoic acids and derivatives thereof
AssigneeG. D. Searle & Co.
InventorRichard A. Mueller
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Abstract
3,5-Bisoxygenated 2-(.omega.-halo-3-oxygenated-1-alkenyl)-cyclopentane-1-heptanoic acids and derivatives thereof, conveniently obtained by processes utilizing 2-formyl-3-hydroxy-5-oxycyclopent-1-eneheptanoic acids as the starting materials, display valuable pharmacological properties, e.g. antifertility, bronchodilating, anti-secretory, smooth muscle stimulatory, and blood platelet aggregation-inhibiting.
Claims12
A compound of the formula ##STR20## wherein R.sub.1 is hydrogen or an alkyl radical containing 1-12 carbon atoms;
- R.sub.2 is hydrogen, a tetrahydropyran-2-yl or trialkylsilyl radical, or alkanoyl radical containing 1-12 carbon atoms;
- X is a carbonyl radical;
- Y is a radical of the formula ##STR21## A being hydrogen or an alkanoyl radical containing 1-12 carbon atoms and B being hydrogen or an alkyl radical containing 1-12 carbon atoms;
- Z is a chloro, bromo, or iodo radical;
- Alk is an alkylene radical containing 3-8 carbon atoms;
- and the wavy lines represent the alternative .alpha. and .beta. stereochemical configuration.
3 more elements
Dependencies are inferred from the claim text.