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US 4,056,536 AGranted
Pyrrolo[2,1-b][3]benzazepines
AssigneeMerck & Co., Inc.
InventorsJoseph G. Atkinson, Patrice C. Belanger, Clarence S. Rooney, Susan F. Britcher
Life of this patent
Estimating the term…
Abstract
11H-Pyrrolo[2,1-b][3]benzazepin-11-one and derivatives thereof are generally prepared by Friedel-Crafts ring closure of a N-styrylpyrrole-2-carboxylic acid derivative. They are useful intermediates in the synthesis of skeletal muscle relaxants and tranquilizers such as 11-(3-dimethylaminopropylidene)-2-cyano-11H-pyrrolo[2,1-b][3]benzazepine.
Claims7
A compound of structural formula:
- ##STR20## wherein n is [3,2,] 1, or 0 (X is hydrogen);
- m is [4, 3, 2,] 1 or 0 (Y is hydrogen);
- and
- X and Y are independently selected from
- (1) hydrogen,
- (2) halo,
- (3) formyl,
- (4) lower alkanoyl,
- (5) lower alkyl,
- (6) lower alkoxycarbonyl,
- (7) hydroxy-lower alkyl,
- (8) perhalo-lower alkyl,
- (9) lower alkoxy,
- (10) cyano,
- (11) perhalo-lower alkylthio,
- (12) lower alkylthio,
- (13) lower alkylsulfonyl,
- (14) perhalo-lower alkylsulfonyl,
- (15) lower alkylsulfinyl,
- (16) perhalo-alkylsulfinyl,
- (17) amino,
- (18) lower alkanoylamino,
- (19) lower alkylamino,
- (20) di(lower alkyl)amino,
- (21) hydroxy,
- (22) N-lower alkylcarbamoyl,
- (23) N,N-di(lower alkyl)carbamoyl,
- (24) nitro,
- (25) di(lower alkyl)sulfamoyl,
- (26) lower alkoxycarbonylamino,
- (27) N-loweralkyl-carbamoyloxy,
- (28) carboxy, and
- (29) carbamoyl.
30 more elements
9-Chloro-11H-pyrrolo[2,1-b] [3]benzazepin-11-one.
Dependencies are inferred from the claim text.