Dibenzopyrimidoazepines
AssigneeJohn Wyeth & Brother Limited
InventorRobin Michael Black
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Abstract
The invention relates to dibenzopyrimidoazepines of the formula (I) ##STR1## and their acid addition and quaternary ammonium salts. In formula (I) R.sup.1 and R.sup.2 each represent hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl and X represents two hydrogen atoms, an oxo group, a protected oxo group or an oximino group. The compounds in which X represents two hydrogen atoms, an oxo group or an oximino group possess hypoglycaemic activity. The compound in which X represents a protected oxo group are intermediates for preparing the compounds in which X is an oxo group. The dibenzopyrimidoazepines may be prepared by cyclising or cyclodehydrating novel morphanthridine derivatives.
Claims6
A dibenzopyrimidoazepine selected from the group consisting of compounds having the formula (I):
- ##STR10## and the pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, wherein R.sup.1 and R.sub.2 each represent hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl and X represents two hydrogen atoms, an oxo group, an ethylene ketal group, a di-(lower alkyl) ketal group, or an oximino group.
Dependencies are inferred from the claim text.