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US 4,056,519 AGranted
Substrate for assay of plasmin
AssigneeEli Lilly and Company
InventorsJesse L. Bobbitt, Edward L. Smithwick, Jr.
Life of this patent
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Abstract
The proteinase plasmin is assayed either colorimetrically or fluorometrically with a tripeptidyl-4-methoxy-2-naphthylamide substrate having the following general formula: ##STR1## The substrate is useful for either routine clinical assays or kinetic studies.
Claims5
A tripeptidyl-4-methoxy-2-naphthylamide having the formula, ##STR3## in which R.sub.1 and R.sub.2 independently are hydrogen, alkyl, hydroxyalkyl, mercaptoalkyl, methylthioalkyl, benzyl, or hydroxybenzyl, with the proviso that at least one of R.sub.1 and R.sub.2 must be other than benzyl or hydroxybenzyl;
- and the acid addition salts thereof in which the acid is inorganic or C.sub.1 -C.sub.2 carboxylic.
Dependencies are inferred from the claim text.