9-(3-O-Acyl-.beta.-D-arabinofuranosyl)adenine compounds, 9-(2,3-di-O-acyl-.beta.-D-arabinofuranosyl)-adenine compounds, and method for their production
AssigneeParke, Davis & Company
InventorsDavid Clarkston Baker, Theodore Herbert Haskell
Life of this patent
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Abstract
9-(3-O-Acyl-.beta.-D-arabinofuranosyl)adenine compounds, 9-(2,3-di-O-acyl-.beta.-D-arabinofuranosyl)adenine compounds, and their production by reacting in each case the corresponding 5-silyl ether derivative with a tetraalkylammonium fluoride. The compounds are useful as antiviral agents. The compounds are water-soluble and lipophilic, thereby being adaptable to a wide variety of pharmaceutical formulations.
Claims10
9-(.beta.-D-Arabinofuranosyl)adenine compounds having the formulas ##STR3## where R is an alkanoyl group having from 2 to 4 carbon atoms.
Method for the production of 9-(3-O-acyl- and 2,3-di-O-acyl-.beta.-D-arabinofuranosyl)adenine compounds having the formulas ##STR4## where R is an alkanoyl group having from 2 to 4 carbon atoms, which comprises reacting a 5-silyl ether derivative represented by the formulas ##STR5## with an equivalent quantity of a tetra(lower)alkylammonium fluroride in the presence of lower alkanoic acid where R is an alkanoyl group having from 2 to 4 carbon atoms, R.sup.1 is lower alkyl, and R.sup.2 and R.sup.3 represent lower alkyl or phenyl or together are tetramethylene.
Dependencies are inferred from the claim text.