Treating arrythmia with phenylthioaralkylamines
AssigneeMerck & Co., Inc.
InventorMarcia Elizabeth Christy
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Abstract
Phenylthioaralkylamines and 2-phenylthiobenzylamines are prepared by reaction of the corresponding phenylthiobenzoyl chloride or homologs thereof with ammonia or an amine to produce the corresponding phenylthiobenzamide or N-substituted or N,N-disubstituted derivative thereof followed by reduction with lithium aluminum hydride to produce the corresponding phenylthiobenzylamine or the N-substituted or N,N-disubstituted derivative thereof. The compounds are also prepared by reaction of the corresponding phenylthiobenzyl halide with ammonia or a selected amine. The compounds are active as antiarrhythmics.
Claims3
Method of treating animals suffering from arrythmia which comprises orally or parenterally administering an antiarrythmia amount of compound having the formula ##STR7## wherein R.sub.2 and R.sub.3 are independently selected from the group consisting of hydrogen C.sub.1 -C.sub.6 alkyl, benzyl, phenethyl, C.sub.2 -C.sub.6 alkenyl and C.sub.2 -C.sub.6 alkynyl;
- X and X' are selected from the group consisting of hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.5 alkoxy, and trifluoromethyl;
- and
- m is an integer selected from the group consisting of 0 to 4 inclusive and non-toxic, pharmacologically acceptable salts thereof.
Dependencies are inferred from the claim text.