Pharmaceutical preparations containing 4-(4-biphenylyl) butylamines and treatment of the animal organism therewith
AssigneeArmour Pharmaceutical Company
InventorMartin O. Skibbe
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Abstract
Preparations containing 4-biphenylyl butylamines or pharmaceutically acceptable salts thereof and methods of using the same whereby a host, including man, to whom such preparations are administered, is provided with anti-inflammatory, antipyretic and analgesic relief while avoiding the unwanted side effects of steroid therapy. The preparations of this invention contain compounds having the structure ##STR1## wherein: R.sub.1 is selected from the group consisting of hydrogen and lower alkyls having from one to four carbon atoms; and R.sub.2 is selected from the group consisting of hydrogen and lower alkyls having from one to four carbon atoms. The pharmaceutically acceptable salts are formed on the same basis structure as shown.
Claims15
A pharmaceutical preparation in unit dosage form selected from the group consisting of a tablet, a filled capsule, a packet, a lozenge, a troche, a solution, a suspension, an emulsion, an ointment, a suppository and a soft gelatin capsule and having, when administered to a host with an inflammatory condition, an anti-inflammatory activity, said preparation comprising a pharmaceutically acceptable carrier and from about 1 mg. to about 2,000 mg. of a member selected from the group consisting of a 4-(4-biphenylyl) butylamine compound having the structure shown below and a non-toxic pharmaceutically acceptable acid salt thereof, said structure being ##STR4## wherein:
- R.sub.1 is selected from the group consisting of hydrogen and a lower alkyl having from one to four carbon atoms;
- and R.sub.2 is selected from the group consisting of hydrogen, and a lower alkyl having from one to four carbon atoms.
The method of treating an inflammatory condition of a host, including man, comprising administering to said host daily from about 1 mg. to about 2,000 mg. of a compound having the structure ##STR5## wherein:
- R.sub.1 is selected from the group consisting of hydrogen and a lower alkyl having from one to four carbon atoms;
- and R.sub.2 is selected from the group consisting of hydrogen, and a lower alkyl having from one to four carbon atoms.
Dependencies are inferred from the claim text.