Cyanomethylphenethanolamines
AssigneeMead Johnson & Company
InventorsWilliam E. Kreighbaum, William L. Matier, Herbert R. Roth
Life of this patent
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Abstract
Preparation of cyanomethylphenethanolamines useful as adrenergic stimulants is described. Preferred compounds such as 2-hydroxy-5-[1-hydroxy-2-[(1,1-dimethyl-2-phenylethyl)amino]ethyl]-benzene acetonitrile are selective beta-adrenergic stimulants having relatively greater potency on respiratory smooth muscle than on cardiac muscle. Such compounds are particularly valuable in the treatment of bronchial conditions.
Claims10
A compound selected from the group of phenethanolamines of the formula ##STR14## or a pharmaceutically acceptable acid addition salt thereof wherein
- R is hydrogen, methyl or ethyl;
- R.sub.1 is hydrogen or a radical selected from the group consisting of straight or branched chain lower alkyl of 1 to 6 carbon atoms inclusive, straight or branched chain lower alkyl of 1 to 6 carbon atoms substituted by phenyl, phenoxy, substituted phenyl or substituted phenoxy wherein said phenyl or phenoxy substituent is hydroxy, methoxy, or halogen.
A pharmaceutical composition in dosage unit form comprising a pharmaceutical carrier and an effective bronchodilating amount of a compound selected from the group of phenethanolamines of the formula ##STR15## or a pharmaceutically acceptable acid salt thereof wherein
- R is hydrogen, methyl or ethyl;
- R.sub.1 is hydrogen or a radical selected from the group consisting of straight or branched chain lower alkyl of 3 to 6 carbon atoms inclusive, straight or branched chain lower alkyl of 1 to 6 carbon atoms substituted by phenyl, phenoxy, substituted phenyl or substituted phenoxy wherein said phenyl or phenoxy substituent is hydroxy, methoxy, or halogen.
A method for effecting bronchodilation in a mammal in need of such treatment which comprises administering to said mammal an effective bronchodilator amount of a compound selected from the group of phenethanolamines of the formula ##STR16## or a pharmaceutically acceptable acid addition salt thereof wherein
- R is hydrogen, methyl or ethyl;
- R.sub.1 is hydrogen or a radical selected from the group consisting of straight or branched chain lower alkyl of 3 to 6 carbon atoms inclusive, straight or branched chain lower alkyl of 1 to 6 carbon atoms substituted by phenyl, phenoxy, substituted phenyl or substituted phenoxy wherein said phenyl or phenoxy substituent is hydroxy, methoxy, or halogen.
Dependencies are inferred from the claim text.