4-Alkyl-2,6-di-(secondary or tertiary alkyl)amino-3-formylpyridines pharmaceutical compositions thereof and their use in the treatment of obesity and diabetes

Abstract

Compounds of the formula ##STR1## wherein R is secondary alkyl of 3 to 7 carbon atoms or tertiary alkyl of 4 to 7 carbon atoms, R' is secondary alkyl of 3 to 7 carbon atoms or tertiary alkyl of 4 to 7 carbon atoms, R.sub.1 is primary or secondary alkyl of 1 to 5 carbon atoms, and R.sub.2 is hydrogen, chloro or bromo, And the pharmaceutically acceptable acid addition salts thereof, are useful as anti-obesity and anti-diabetic agents. The compounds wherein R and R' are tertiary alkyl of 4 to 7 carbon atoms and R.sub.2 is hydrogen are synthesized from ketenimines and amidines, all of the compounds wherein R.sub.2 is hydrogen are synthesized by reduction of the corresponding 3-cyanopyridines, and the compounds wherein R.sub.2 is chloro or bromo are synthesized from the corresponding compounds wherein R.sub.2 is hydrogen and an N-halosuccinimide.

Dependencies are inferred from the claim text.