Condensed pyrrole mercapto compounds having hypotensive and decongestant properties
AssigneeCiba-Geigy Corporation
InventorsVishwa Prakash Arya, Kuppuswamy Nagarajan
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Abstract
The present invention relates to condensed pyrrole mercapto compounds, especially to optionally substituted indole or aza-indole mercapto derivatives, which compounds have ophthalmological and hypotensive properties, in particular vasoconstrictor, especially decongestant properties. It further relates to pharmaceutical compositions containing these compounds. An illustrative example is 3-(2-imidazolin-2-ylthio)-indole hydrochloride or hydroiodide.
Claims3
A pharmaceutical composition having vasoconstrictor and blood pressure lowering properties comprising a therapeutically effective amount of a compound of formula Ia ##STR13## wherein X is nitrogen or the group CH, and each of R.sub.a and R.sub.b is hydrogen, lower alkyl, halogen or a lower alkoxy group, each of R.sub.1 and R.sub.3 independently is hydrogen or a lower alkyl group, R.sub.2 is hydrogen, lowr alkyl, a free carboxy group of a methoxy- or ethoxycarbonyl group and n is an integer denoting 2-4, or its tautomers or acid addition salts together with a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.