Furo(3,4-E)-as-triazines and corresponding 4-oxides as sleep inducers and minor tranquilizers
AssigneeSandoz Ltd.
InventorGregory B. Bennett
Life of this patent
Estimating the term…
Abstract
5,5,7,7-tetramethyl-3-substituted or unsubstituted-phenylfuro[3,4-e]-as-triazines and corresponding 4-oxides, e.g., 5,7-dihydro-5,5,7,7-tetramethyl-3-phenylfuro[3,4-e]-as-triazine and 5,7-dihydro-5,5,7,7-tetramethyl-3-phenylfuro[3,4-e]-as-triazine-4-oxide, are prepared from 2,2,5,5-tetramethyl-3,4(2H,5H)-furandione-3-hydrazone-4-oximes and are useful as sleep inducers and minor tranquilizers.
Claims3
A method of inducing sleep in animals which comprises administering to an animal in need of such treatment a sleep-inducing effective amount of a compound of the formula ##STR11## wherein R.sub.1 and R.sub.2 each independently represent hydrogen, halo having an atomic weight of about 19 to 36, lower alkyl, straight chain lower alkoxy, amino, nitro or trifluoromethyl, and
- X represents ##STR12## provided that i. when one of R.sub.1 and R.sub.2 represents nitro, the other is other than nitro or trifluoromethyl;
- ii. when R.sub.1 and R.sub.2 represent trifluoromethyl, they are on other than adjacent carbon atoms, and
- iii. when R.sub.1 and R.sub.2 represent t-butyl, they are on other than adjacent carbon atoms, and
- iv. when one of R.sub.1 and R.sub.2 is trifluoromethyl and the other is t-butyl, they are on other than adjacent carbon atoms.
A method of treating tension in animals which comprises administering to an animal in need of such treatment a tranquilizing effective amount of a compound of the formula ##STR13## wherein R.sub.1 and R.sub.2 each independently represent hydrogen, halo having an atomic weight of about 19 to 36, lower alkyl, straight chain lower alkoxy, amino, nitro or trifluoromethyl, and
- X represents ##STR14## provided that i. when one of R.sub.1 and R.sub.2 represents nitro, the other is other than nitro or trifluoromethyl;
- ii. when R.sub.1 and R.sub.2 represent trifluoromethyl, they are on other than adjacent carbon atoms, and
- iii. when R.sub.1 and R.sub.2 represent t-butyl, they are on other than adjacent carbon atoms, and
- iv. when one of R.sub.1 and R.sub.2 is trifluoromethyl and the other is t-butyl, they are on other than adjacent carbon atoms.
A pharmaceutical composition for use in treating tension or inducing sleep comprising a therapeutically effective amount of a compound of the formula ##STR15## wherein R.sub.1 and R.sub.2 each independently represent hydrogen, halo having an atomic weight of about 19 to 36, lower alkyl, straight chain lower alkoxy, amino, nitro or trifluoromethyl, and
- X represents ##STR16## provided that i. when one of R.sub.1 and R.sub.2 represents nitro, the other is other than nitro or trifluoromethyl;
- ii. when R.sub.1 and R.sub.2 represent trifluoromethyl, they are on other than adjacent carbon atoms, and
- iii. when R.sub.1 and R.sub.2 represent t-butyl, they are on other than adjacent carbon atoms, and
- iv. when one of R.sub.1 and R.sub.2 is trifluoromethyl and the other is t-butyl, they are on other than adjacent carbon atoms,
- in association with a pharmaceutically acceptable diluent or carrier therefor.
Dependencies are inferred from the claim text.