Imidazolyl-2-quinazoline derivatives

Compounds of formula I, ##STR43## in which R.sub.1 is hydrogen, lower alkyl of 1 to 4 carbon atoms or halogen,

• R.sub.2 is lower alkyl of 1 to 6 carbon atoms, lower alkenyl of 2 to 6 carbon atoms or lower hydroxyalkyl of 1 to 6 carbon atoms,
• and
• R.sub.3 is
• a. a group of formula II, ##STR44## in which X is oxygen or sulphur,
• D is straight or branched chain alkylene of 1 to 6 carbon atoms
• and either
• R.sub.4 is hydrogen or lower alkyl of 1 to 4 carbon atoms
• and
• R.sub.5 is lower alkyl of 1 to 4 carbon atoms or lower hydroxyalkyl of 1 to 4 carbon atoms
• or
• R.sub.4 and R.sub.5, together with the nitrogen atom to which they are attached, is piperidino or piperazino, unsubstituted or substituted by lower alkyl of 1 to 4 carbon atoms or lower hydroxyalkyl of 1 to 4 carbon atoms.
• b. a group of formula III, ##STR45## in which m is 0 or 1, and
• Y is oxygen or sulphur, or imino, unsubstituted or substituted by lower alkyl of 1 to 4 carbon atoms or lower hydroxyalkyl of 1 to 4 carbon atoms
• c. a group of formula IV, ##STR46## in which Z is --NH--or ##STR47## d. a group of formula V, ##STR48## in which m, R.sub.1 and R.sub.2 are as defined above, the m's, the R.sub.1 's and the R.sub.2 's then being the same,
• e. a group of formula VI, ##STR49## in which Z is a defined above, and
• either
• A is oxygen or sulphur and B is --CH--,
• or
• A is sulphur or --N(R.sub.6)--, in which R.sub.6 is lower alkyl of 1 to 4 carbon atoms or lower hydroxyalkyl of 1 to 4 carbon atoms,
• and
• B is nitrogen,
• or
• f. a group of formula VII, ##STR50## in which D is a defined above, and
• R.sub.9 is hydrogen, lower alkyl of 1 to 4 carbon atoms or lower hydroxyalkyl of 1 to 4 carbon atoms
• and chemotherapeutically acceptable acid addition salts thereof.