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US 4,055,597 AGranted
10-Aza-11,12-secoprostaglandins
AssigneeMerck & Co., Inc.
InventorsEdward J. Cragoe, Jr., John B. Bicking
Life of this patent
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Abstract
This invention relates to 10-aza-11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators.
Claims14
The compound having the following formula:
- ##STR32## wherein R is carboxy or a carboxy salt having the formula --COO.sup.- Me.sup.+ wherein Me is a pharmaceutically-acceptable cation derived from a metal or an amine;
- A is ethylene, trimethylene, .alpha.-methylethylene, .beta.-methylethylene, .alpha.,.alpha.-dimethylethylene, or .beta.,.beta.-dimethylethylene;
- R.sup.1 is hydrogen or methyl;
- R.sup.2 is hydrogen or alkyl or 1-3 carbon atoms;
- R.sup.3 is hydrogen or methyl;
- R.sup.4 is hydrogen;
- and
- R.sup.5 is loweralkyl of 3-7 carbon atoms, 4-pentenyl, or 5,5,5-trifluoropentyl;
- except that when R.sup.3 is methyl, R.sup.5 is limited to propyl, butyl, pentyl, 4-methylpentyl, 4,4-dimethylpentyl, hexyl, heptyl, and 5,5,5-trifluoropentyl.
6 more elements
Dependencies are inferred from the claim text.