11,12-Seco-prostaglandins
AssigneeMerck & Co., Inc.
InventorsEdward J. Cragoe, Jr., James H. Jones
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Abstract
The invention is concerned with novel 16-aryloxy-, 16-alkoxy-, 16-arylthio- and 16-alkylthio-8-aza-9-dioxothia-11,12-seco-prostaglandins and processes for their preparation. These novel compounds are useful as pharmaceuticals since they can be used in animals for estrus synchronization and treatment of infertility due to persistence of luteal function.
Claims7
The compound of the formula ##STR29## wherein R is selected from the group consisting of carboxy and a carboxy salt, said carboxy salt being formed from a pharmaceutically acceptable cation, and alkoxycarbonyl of the formula --COOAlk wherein Alk is alkyl having 1-10 carbon atoms;
- p1 R.sup.1 is hydrogen or lower alkanoyl;
- A is selected from the group consisting of methylene or oxygen;
- Y is selected from the group consisting of ethylene, vinylene, or ethynylene;
- Z is selected from the group consisting of ethylene, vinylene, or ethynylene;
- R.sup.2 is --O--R.sup.5 or --S--R.sup.5 wherein R.sup.5 is lower alkyl or fluorinated lower alkyl.
Dependencies are inferred from the claim text.