Substituted aryloxy-3,3,3-trifluoro-2-propionic acids, esters and salts thereof
AssigneeImperial Chemical Industries PLC
InventorsDavid Bryan Haydock, Thomas Patrick Cunningham Mulholland, Jeffrey Meyrick Thorp
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Abstract
Derivatives of 2-hydroxy-3,3,3-trifluoro-2-(alkyl or trifluoromethyl)propionic acid bearing a phenyl or naphthyl group linked to the 2-hydroxy group either directly or via an intermediate methylene group. The compounds reduce the concentrations of cholesterol, total esterified fatty acids or fibrinogen in the blood plasma of test animals and some compounds show anti-arthritic properties.
Claims8
A fluorinated compound of the formula:- ##STR9## wherein Ar is a phenyl or naphthyl radical which, may optionally bear as substituent a halogen atom, an alkyl radical of 1-4 carbon atoms or an alkoxy radical of 1-4 carbon atoms, or a phenyl or phenoxy radical which may itself bear as substituent a halogen atom, an alkyl radical or 1-4 carbon atoms or an alkoxy radical of 1-4 carbon atoms;
- X is --CH.sub.2 --;
- R.sup.1 is a hydroxy radical or an alkoxy radical of 1-6 carbon atoms;
- and R.sup.2 is a hydrogen atom, a methyl radical or a trifluoromethyl radical;
- or, for a compound wherein R.sup.1 is a hydroxy radical, a pharmaceutically acceptable base addition salt thereof.
Dependencies are inferred from the claim text.