20-Alkoxy-16-alkyl prostadienoic acid derivatives
AssigneeYamanouchi Pharmaceutical Co., Ltd.
InventorsNoriyoshi Inukai, Masuo Murakami, Hidenori Iwamoto, Isao Yanagisawa, Toshinari Tamura, Yoshio Ishii, Kenichi Tomioka, Tetsuya Shiozaki, deceased
Life of this patent
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Abstract
A 20-alkoxy-16-alkyl-prostadienoic acid derivative shown by the formula ##STR1## wherein A represents ##STR2## R and R.sup.5, which may be the same or different, each represents a hydrogen atom or a lower alkyl group; and R.sup.1 and R.sup.4, which may be the same or different, each represents a lower alkyl group, And the pharmacologically acceptable nontoxic salts thereof. The compounds have excellent effects as prostaglandin E.sub.2 and prostaglandin F.sub.2.alpha..
Claims4
A 20-alkoxy-16-alkylprostadienoic acid derivative shown by the formula ##STR11## wherein A represents ##STR12##
- R and R.sup.5, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, and R.sup.1 and R.sup.4, which may be the same or different, each represents a lower alkyl group
A 20-alkoxy-16-alkylprostadienoic acid derivative shown by the formula ##STR13## wherein R represents a hydrogen atom of a lower alkyl group and R.sup.1 and R.sup.4, which may be the same or different, each represents a lower alkyl group and the pharmacologically acceptable nontoxic salts thereof.
11.alpha.,15(S)-Dihydroxy-20-methoxy-16-methyl-9-oxo-5(cis)-13(t rans)prostadienoic acid and the pharmacologically acceptable salts thereof.
11.alpha.,15(S)-Dihydroxy-20-methoxy-16-methyl-9-oxo-5(cis)-13(trans)pro stadienoic acid methyl ester.
Dependencies are inferred from the claim text.