Cyano intermediates for prostaglandins
AssigneeThe Upjohn Company
InventorDavid R. White
Life of this patent
Estimating the term…
Abstract
Intermediates for preparing prostaglandins, represented by the formula ##STR1## wherein L.sub.3 represents ##STR2## and wherein R.sub.25 is hydrogen or tetrahydropyranyl or similar group as defined herein. These cyano intermediates are useful intermediates in preparing prostaglandin analogs having pharmacological utility.
Claims5
An optically active compound of the formula ##STR10## or a mixture of that compound and the enantiomer thereof, wherein L.sub.3 represents ##STR11## and wherein R.sub.25 is hydrogen, 1-ethoxyethyl, tetrahydropyranyl, tetrahydrofuranyl, or a group of the formula ##STR12## wherein R.sub.17 is alkyl of one to 17 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl or phenyl substituted with one, 2, or 3 alkyl of one to 4 carbon atoms, inclusive, wherein R.sub.18 and R.sub.19 are the same or different, being hydrogen, alkyl of one to 4 carbon atoms, inclusive, phenyl or phenyl substituted with one, 2, or 3 alkyl of one to 4 carbon atoms, inclusive, or, when R.sub.18 and R.sub.19 are taken together, --(CH.sub.2).sub.a -- or --(CH.sub.2).sub.b --O--(CH.sub.2).sub.c -- wherein a is 3, 4, or 5, b is one, 2, 3, and c is one, 2, or 3 with the proviso that b plus c is 2, 3, or 4, and wherein R.sub.20 is hydrogen or phenyl;
- with the further proviso that both R.sub.25 's are the same.
Dependencies are inferred from the claim text.