A compound of the formula ##STR35## wherein each R.sub.1 is independently halo, C.sub.1-8 alkyl, substituted C.sub.1-8 alkyl, C.sub.5-8 cycloalkyl, substituted C.sub.5-8 cycloalkyl, C.sub.1-8 alkoxy, substituted C.sub.1-8 alkoxy, C.sub.5-8 cycloalkyloxy, substituted C.sub.5-8 cycloalkyloxy, trifluoromethyl or nitro,
- R.sub.2 is carboxy, carbamoyl, (C.sub.1-8 alkyl)carbamoyl, (substituted C.sub.1-8 alkyl)carbamoyl, (C.sub.5-8 cycloalkyl)carbamoyl, (substituted C.sub.5-8 cycloalkyl)carbamoyl, di-(C.sub.1-8 alkyl)carbamoyl, di-(substituted C.sub.1-8 alkyl)carbamoyl, N-C.sub.1-8 alkyl-N-(substituted C.sub.1-8 alkyl)carbamoyl, phenylcarbamoyl, substituted phenylcarbamoyl, (C.sub.1-8 alkoxy)carbonyl, (substituted C.sub.1-8 alkoxy)carbonyl, (C.sub.5-8 cycloalkyloxy)carbonyl, (substituted C.sub.5-8 cycloalkyloxy)carbonyl, phenoxycarbonyl, substituted phenoxycarbonyl or cyano, ##STR36## when m is 2, wherein R.sub.5 is phenyl;
- phenyl substituted by 1-3 substituents each of which is independently chloro, bromo, methyl, methoxy or trifluoromethyl or benzimidazolonyl-5,
- R.sub.6 is hydroxy or amino,
- R.sub.7 is hydrogen, methyl, phenyl, methoxycarbonyl or ethoxycarbonyl,
- R.sub.8 is hydrogen, methyl, ethyl, phenyl or phenyl substituted by 1-3 substituents each of which is independently chloro, bromo, cyano, nitro, methyl, methoxy or ethoxy,
- R.sub.9 is hydrogen;
- methyl;
- formamido;
- (C.sub.1-4 alkyl)carbonylamino;
- (C.sub.1-4 alkyl)carbonylamino monosubstituted by chloro, bromo, phenyl, C.sub.1-4 alkoxy or phenoxy;
- (C.sub.1-4 alkoxy)carbonylamino;
- (C.sub.1-4 alkoxy)carbonylamino monosubstituted by chloro, bromo, phenyl, C.sub.1-4 alkoxy or phenoxy;
- C.sub.1-4 alkylsulfonylamino or C.sub.1-4 alkylsulfonylamino monosubstituted by chloro, bromo, phenyl, C.sub.1-4 alkoxy or phenoxy,
- R.sub.10 is hydrogen, methoxy or ethoxy,
- R.sub.11 is C.sub.1-4 alkyl or C.sub.1-4 alkyl or C.sub.1-4 alkyl monosubstituted by chloro, bromo, cyano, hydroxy, methoxy, ethoxy, phenyl, phenoxy, (C.sub.1-4 alkyl)carbonylamino, (C.sub.1-4 alkyl)carbonyloxy, (C.sub.1-4 alkoxy)carbonyl or (C.sub.1-4 alkoxy)carbonyloxy,
- R.sub.12 is hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkyl monosubstituted by chloro, bromo, cyano, hydroxy, methoxy, ethoxy, phenyl, phenoxy, (C.sub.1-4 alkyl)carbonylamino, (C.sub.1-4 alkyl)carbonyloxy, (C.sub.1-4 alkoxy)carbonyl or (C.sub.1-4 alkoxy)carbonyloxy,
- R.sub.13 is hydrogen, phenyl, amino, C.sub.1-4 alkylamino, di-(C.sub.1-4 alkyl)amino, C.sub.1-4 alkyl or C.sub.1-4 alkyl monosubstituted by chloro, bromo, cyano, hydroxy, methoxy, ethoxy, phenyl, phenoxy, (C.sub.1-4 alkyl)carbonylamino, (C.sub.1-4 alkyl)carbonyloxy, (C.sub.1-4 alkoxy)carbonyl or (C.sub.1-4 alkoxy)carbonyloxy, and
- X is a direct bond, ##STR37## wherein R.sub.14 is two hydrogen, --SO.sub.2 --, --NH--, --O-- or --S, R.sub.15 is --O--, --S--, --CH.sub.2 --, --NH--, --CO-- or --SO.sub.2 --,
- each R.sub.16 is independently chloro, bromo, nitro, cyano, trifluoromethyl, methyl, methoxy, ethoxy, methoxycarbonyl or ethoxycarbonyl, and
- n is 0, 1 or 2,
- m is 1 or 2, and
- n is 0, 1 or 2,
- wherein each substituted C.sub.1-8 alkyl and substituted C.sub.1-8 alkoxy group and moiety independently has 1 or 2 substituents each of which is independently halo, cyano, hydroxy, C.sub.1-4 alkoxy, phenyl, phenoxy, acyl, acyloxy or acylamino,
- each substituted C.sub.5-8 cycloalkyl and substituted C.sub.5-8 cycloalkyloxy group and moiety independently has 1 or 2 substituents each of which is independently C.sub.1-4 alkyl, halo, cyano, hydroxy, C.sub.1-4 alkoxy, phenyl, phenoxy, acyl, acyloxy or acylamino,
- each substituted phenyl and substituted phenoxy moiety independently has 1 or 2 substituents each of which is independently nitro, C.sub.1-4 alkyl, halo, cyano, hydroxy, C.sub.1-4 alkoxy, phenyl, phenoxy, acyl, acyloxy or acylamino,
- each acyl and acyl moiety of acyloxy and acylamino is independently R--Y-- or R'--Z--,
- wherein R is C.sub.1-4 alkyl;
- C.sub.1-4 alkyl substituted by 1 or 2 substituents each of which is independently halo, cyano, hydroxy, C.sub.1-4 alkoxy, phenyl or phenoxy;
- phenyl or phenyl substituted by 1 or 2 substituents each of which is independently nitro, C.sub.1-4 alkyl, halo, cyano, hydroxy, C.sub.1-4 alkoxy, phenyl or phenoxy,
- Y is --O--CO--, --SO.sub.2 -- or --OSO.sub.2 --,
- Z is --CO--, --NR'--CO-- or --NR'--SO.sub.2 --, and
- R' is hydrogen;
- C.sub.1-4 alkyl;
- C.sub.1-4 alkyl substituted by 1 or 2 substituents each of which is independently halo, cyano, hydroxy, C.sub.1-4 alkoxy, phenyl or phenoxy;
- phenyl or phenyl substituted by 1 or 2 substituents each of which is independently nitro, C.sub.1-4 alkyl, halo, cyano, hydroxy, C.sub.1-4 alkoxy, phenyl or phenoxy, and
- each halo is independently fluoro;
- chloro or bromo.