US 4,055,524 A · Synthesis of peptides

Abstract

Resin peptides useful in the preparation of peptides having biological activity, and particularly such resin peptides containing R-CH.sub.2 -Phe-Glu at one end of an amino acid chain, R being the resin and Phe and Glu being the residues of the amino acids phenylalanine and glutamic acid; and processes for the preparation of such resin peptides. Resin peptides are disclosed which contain amino acid chains identical with the amino acid chains of natural peptides having biological activity. Other resin peptides are disclosed which contain amino acid chains in which the amino acid residues differ in kind and sequence from amino acid chains of natural biologically active peptides but from which peptides having biological activity may be derived.

Claims13

Dependent claims

A resin peptide having the structure:

##STR23## in which Bz is benzyl, p-methoxybenzyl, p-chlorobenzyl, p-nitrobenzyl or benzylhydryl and
R is divinylbenzene crosslinked polystyrene resin.

Dependencies are inferred from the claim text.

Facts

Application

05/603,771Filed 11 Aug 1975 · continuation in part

Priority

12 Feb 1974

Granted

25 Oct 1977

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

C08H 1/00
Macromolecular products derived from proteins
C07K 1/042
On carriers: characterised by the nature of the carrier
C07K 14/695
Derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin: corticotropin [ACTH]
C08F 8/30
Chemical modification by after-treatment: introducing nitrogen atoms or nitrogen-containing groups

Synthesis of peptides

Life of this patent

Synthesis of peptides

Life of this patent

Abstract

Claims13