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US 4,054,659 AGranted
5,7 Dihydroxy-1-(trimethoxybenzyl)-1,2,3,H-tetrahydroisoquinolines and use thereof
AssigneeTanabe Seiyaku Co., Ltd.
InventorsMuneyoshi Ikezaki, Kunihiko Irie, Norihide Umino, Katsuo Ikezawa, Masanori Sato
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Abstract
A novel 5,7-dihydroxytetrahydroisoquinoline derivative having the formula: ##STR1## wherein R is trimethoxyphenyl, is prepared either by hydrolysis of a compound having the formula: ##STR2## wherein R.sup.1 is an organic acyl group and R is same as above, or by catalytic hydrogenation of a compound having the formula: ##STR3## wherein R.sup.3 is hydrogen or benzyl and R is same as above. The 5,7-dihydroxytetrahydroisoquinoline derivative (I) or a pharmaceutically acceptable acid addition salt thereof is useful as a bronchodilator.
Claims4
A compound of the formula:
- ##STR7## wherein R is trimethoxyphenyl, or a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.