Isoindolin-1-one derivatives
AssigneeRhone-Poulenc Inc.
InventorsClaude Cotrel, Claude Jeanmart, Mayer Naoum Messer
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Abstract
Isoindolin-1-one derivatives substituted on the nitrogen atom in the 2-position by an unsubstituted or substituted phenyl radical or a heterocyclic radical having aromatic characteristics, substituted in the 3-position by a 3-amino(or substituted amino)-2-hydroxy-propoxy group, and optionally substituted in the 5- and/or 6-positions by one or two alkoxy radicals or optionally substituted in the 5- and 6-positions by a methylenedioxy radical, possess pharmacodynamic properties, and are especially useful as antiarrhythmic agents.
Claims5
An isindoline of the formula:
- ##STR8## wherein Ar is pyridazinyl, unsubstituted or substituted by methyl, X and Y when taken singly represent hydrogen or alkoxy of 1 through 4 carbons atoms, or X and Y when taken together represent methylenedioxy, and R.sub.1 and R.sub.2 represent hydrogen or alkul of 1 through 4 carbon atoms, and non-toxic pharmaceutically acceptable acid addition salts thereof.
An isoindoline derivative according to claim 19 wherein R.sub.1 represents isopropyl or t.-butyl and R.sub.2 represents hydrogen.
Dependencies are inferred from the claim text.