Method of contraception
AssigneeRichardson-Merrell Inc.
InventorsHarvey D. Benson, Joyce Francis Grunwell, John O'Neal Johnston, Vladimir Petrow
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Abstract
A method of contraception which comprises administering a compound of the following general formula: ##STR1## wherein R is --CHO or --CH.sub.2 OR.sub.1 ; each of R.sub.1 and R.sub.2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, benzoyl, phenylalkylcarbonyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched or cycloalkylcarbonyl wherein the cycloalkyl moiety has from 5 to 10 carbon atoms; R.sub.3 is hydrogen; or R.sub.2 and R.sub.3 together form a double bond between the 17-position carbon atom and the oxygen atom either alone or in combination with a progestogen.
Claims28
A method of contraception in a patient in need thereof which comprises administering to said patient a contraceptive effective amount of a compound of the formula:
- ##STR9## wherein R is --CHO or --CH.sub.2 OR.sub.1 ;
- each of R.sub.1 and R.sub.2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, benzoyl, phenylalkylcarbonyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched or cycloalkylcarbonyl wherein the cycloalkyl moiety has from 5 to 10 carbon atoms;
- R.sub.3 is hydrogen;
- or R.sub.2 and R.sub.3 together form a double bond between the 17- position carbon atom and the oxygen atom.
A method of contraception in a patient in need thereof which comprises administering to said patient a contraceptive effective amount of an androstene compound of the formula:
- ##STR10## wherein R is --CHO or --CH.sub.2 OR.sub.1 ;
- each of R.sub.1 and R.sub.2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, benzoyl, phenylalkylcarbonyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched or cycloalkylcarbonyl wherein the cycloalkyl moiety has from 5 to 10 carbon atoms;
- R.sub.3 is hydrogen;
- or R.sub.2 and R.sub.3 together form a double bond between the 17- position carbon atom and the oxygen atom;
- in combination with a non-ovulation inhibiting amount of a progestogen.
An oral contraceptive composition in solid unit dosage form which comprises a contraceptive effective amount of a compound of the formula:
- ##STR11## wherein R is --CHO or --CH.sub.2 OR.sub.1 ;
- each of R.sub.1 and R.sub.2 is hydrogen alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, benzoyl, phenylalkylcarbonyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched or cycloalkylcarbonyl wherein the cycloalkyl moiety has from 5 to 10 carbon atoms;
- R.sub.3 is hydrogen;
- or R.sub.2 R.sub.3 together form a double bond between the 17- position carbon atom and the oxygen atom;
- a non-ovulation inhibiting amount of a progestogen and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.