Radiodiagnostic complexes employing fluorine-containing tin reducing agents
AssigneeMinnesota Mining and Manufacturing Company
InventorsBrian K. Hill, Verna M. Kubik
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Abstract
Radiodiagnostic agents for use in mammalian bodies comprising a radiocomplex which is the reaction product of Tc99m-pertechnetate ion, a diagnostic ligand and a tin (II) reducing agent selected from the group consisting of SnF.sub.2, MSnF.sub.3, MSn.sub.2 F.sub.5 and mixtures thereof, wherein M is NH.sub.4, Na, K, Li, Rb or Cs. Radiocomplex precursor compositions and methods of making the radiocomplex and radiodiagnostic agents are described.
Claims14
An intravenously injectable diagnostic solution for use in mammalian bodies which is an aqueous solution comprising a target-specific radiocomplex, said radiocomplex comprising the reaction product of an aqueous mixture of (a) Tc99m-pertechnetate ion, (b) a target-specific diagnostic ligand, and (c) a tin (II) reducing agent for said pertechnetate ion selected from the group consisting of SnF.sub.2, MSnF.sub.3 and MSn.sub.2 F.sub.5, and mixtures thereof, wherein M is NH.sub.4, Na, K, Li, Rb or Cs.
An aseptic, stable pharmaceutical composition for the preparation of an intravenously injectable radiodiagnostic solution containing a target-specific radiocomplex for mammalian bodies, said composition being a radiocomplex precursor composition comprising a mixture of a target-specific diagnostic ligand and a fluorine-containing tin (II) compound selected from the group consisting of SnF.sub.2, MSnF.sub.3, MSn.sub.2 F.sub.5, and mixtures thereof wherein M is NH.sub.4, Na, K, Li, Rb or Cs.
A process for the preparation of a target-specific radiocomplex for use in mammalian body diagnosis comprising
- a. reducing, in aqueous solution, Tc-99m-pertechnetate ion to a 99m-technetium species having an oxidation state greater than zero but less than +7 with a reducing agent comprising a fluorine-containing tin (II) compound selected from the group consisting of SnF.sub.2, MSnF.sub.3, MSn.sub.2 F.sub.5, and mixtures thereof, wherein M is NH.sub.4, Na, K, Li, Rb or Cs,
- b. complexing said reduced 99m-technetium species with a target specific radiodiagnostic ligand.
Dependencies are inferred from the claim text.