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US 4,054,606 AGranted
Process for the preparation of ketone derivatives
AssigneeFirmenich SA
InventorFerdinand Naf
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Abstract
Process for the preparation of .alpha.-substituted cyclic ketones which comprises reacting a magnesium enolate with an aldehyde. The products obtained in accordance with the process of the invention are useful intermediates for the preparation of perfume and flavor ingredients, as well as for the synthesis of certain carotenoids.
Claims9
A process for the preparation of .alpha.-substituted cyclic ketone compounds,
- of the formula ##STR7## wherein R represents a saturated, a mono- or poly-unsaturated, linear or branched, substituted or unsubstituted univalent hydrocarbon radical;
- which comprises reacting an enolate of formula ##STR8## wherein X represents a halogen, with an aldehyde of the formula
- R--CHO (I)
- wherein R is as defined above;
- wherein the reaction is effected at a temperature of from about -15.degree. to about 0.degree. C, is carried out in an inert apolar or weakly polar organic solvent, and wherein the condensation products are subject to acidification.
2 more elements
Dependencies are inferred from the claim text.