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AssigneeAmerican Home Products Corporation
InventorsDieter H. Klaubert, John H. Sellstedt, Charles J. Guinosso
Estimating the term…
The 2-cyano-3-or 4-(substituted amino)oxanilic acid derivatives of the formula: ##STR1## in which the group ##STR2## appears in the designated 3- or 4- position and R is -H; an alkali metal; .sup.+ NH.sub.4 ; alkyl of 1 to 6 carbon atoms, inclusive; aralkyl of 7 or 8 carbon atoms; or cycloalkyl of 5 or 6 carbon atoms; R.sup.1 is --H or alkyl of 1 to 9 carbon atoms; R.sup.2 is --H, alkyl of 1 to 9 carbon atoms or cycloalkyl of 3 to 6 carbon atoms; R.sup.1 and R.sup.2, together, with the nitrogen atom to which they are attached, are aziridinyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, 4-lower alkyl-piperazinyl, morpholino or thiomorpholino; and pharmaceutically acceptable acid addition salts thereof are anti-allergic agents.
A compound of the formula:
Dependencies are inferred from the claim text.
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From the US filing history. Foreign family members aren’t listed.
Substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals: with the ring…
With hetero atoms directly attached in positions 2 and 4: two oxygen atoms, e.g. isatoic anhydride
Heterocyclic compounds
Term ended 18 Oct 1994 (estimated)
USPTO file history isn’t available for this patent, so only indexed dates are shown.
Atopic allergic reactions are of the immediate hypersensitivity type as opposed to delayed hypersensitivity reactions, the latter being involved in such things as tuberculin sensitivity, transplant rejection, contact dermatitis and the like. Commonly recognized clinical conditions known to be at least in part due to atopic immediate hypersensitivity reactions, include seasonal and perennial allergic rhinitis (hay fever) and asthma, anaphylaxis, urticaria, conjunctivitis, angioaedema, eczema, various food and drug reactions and insect sting reactions. The substances most frequently responsible for atopic allergic reactions are plant pollen, animal feathers and danders, dust, milk and wheat, whether inhaled or injested. Atopic hypersensitivity is found in man, dog and other animals although its occurrence is exceptionally found in the lower animals.
Atopic (immediate hypersensitivity) reactions are characterized by the immunopathologic mechanism, the elements of which are: (1) a specific immunoglobulin (antibody; IgE in man, or homocytotropic antibody in the rat) is produced; (2) it is fixed to the surface of a target cell; (3) an antigen or allergin combines with the cell-bound antibody, which (4) induces release of one or more pharmacologic mediators, which in turn (5) induces symptoms of clinical disease such as increased vascular permeability, smooth muscle contraction, mucous gland hypersecretion, leukotaxis (especially eosinophilotaxis) and irritation of sensory nerve endings.
A compound which will interfere with the antigen-IgE reaction to prevent the release of mediators from the mast cell, or permit a non-productive antigen-antibody reaction without release of mediators, of necessity blocks the atopic allergic reaction thereby avoiding the resultant changes which are symptomatic of the disease.