Hexahydro pyridine [1,2d] dibenza [b,f] (1,4)-diazepines
AssigneeAkzona Incorporated
InventorWillem Jacob van der Burg
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Abstract
The invention discloses novel compounds of the general formula: ##STR1## and salts thereof, IN WHICH THE AMINO(ALKYL) MOIETY IS PRESENT AT POSITION 2 OR 3 AND IN WHICH X stands for oxygen, sulphur, the group >NR.sub.7 or the group --CR.sub.9 R.sub.9 --; R.sub.1, r.sub.2, r.sub.3 and R.sub.4 represent hydrogen, hydroxy, halogen, alkyl (1-6 C), alkoxy (1-6 C), alkylthio (1-6 C) or trifluoromethyl; R.sub.5 and R.sub.6 represent hydrogen, alkyl (1-6 C), aralkyl (7-10 C) or together in combination with the nitrogen atom a heterocyclic five- or six-membered ring; R.sub.7 stands for hydrogen or alkyl (1-4 C); R.sub.8 and R.sub.9 stand for hydrogen or methyl and is the number 0, 1, 2 or 3, Having valuable central nervous system (CNS) activities, especially antidepressant activity.
Claims5
A compound of the formula:
- ##STR21## or a pharmaceutically acceptable salt thereof, wherein the group ##STR22## is present at position 2 or 3 in which:
- X represents the group NR.sub.7,
- R.sub.1, r.sub.2, r.sub.3 and R.sub.4 represent hydrogen, hudroxy, halogen, alkyl containing 1 to 6 carbon atoms, alkoxy containing 1 to 6 carbon atoms, alkylthio containing 1 to 6 carbon atoms or trifluoromethyl,
- R.sub.5, r.sub.6 represent hydrogen, alkyl containing 1 to 6 carbon atoms, phenylalkyl in which the alkyl group contains 1 to 4 carbon atoms, or R.sub.5 together with R.sub.6 and the nitrogen atom represent a hererocyclic 5 or 6 membered ring selected from the group consisting pyrrolino, pyrrolidino, piperidino, oxazolidino, morpholino, and piperazino,
- R.sub.7 represents hydrogen or alkyl containing 1 to 4 carbon atoms, and
- n is the number 0, 1, 2 or 3.
A compound of the formula:
- ##STR23##
Dependencies are inferred from the claim text.