Process for preparing N-mono(alkoxymethyl) phenobarbitals
AssigneeBristol-Myers Company
InventorsJulius A. Vida, Carlos M. Samour
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Abstract
N-mono (alkoxymethyl)phenobarbitals wherein the alkoxy group has 1 to 4 carbon atoms are disclosed. The compounds are prepared by reacting the dialkali metal salt of thiophenobarbital with chloromethyl alkyl ether followed by treating the resultant N,S-bis(alkoxymethyl)thiophenobarbital with an oxidizing agent. The compounds are useful as anticonvulsant agents.
Claims6
A process for preparing N-mono(alkoxymethyl)phenobarbital which comprises reacting a dialkali metal salt of thiophenobarbital with chloromethyl alkyl ether wherein the alkyl group has from 1 to 4 carbon atoms in the presence of an inert solvent to provide an N,S-bis(alkoxymethyl) thiophenobarbital and then oxidizing said N,S-bis(alkoxymethyl)thiophenobarbital.
Dependencies are inferred from the claim text.