Thiazole alkanoic acids, hypolipemiant compositions containing them and methods of inducing hypolipemic activity utilizing them
AssigneeRoussel Uclaf
InventorsAndre Poittevin, Vesperto Torelli
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Abstract
Novel thiazole derivatives of the formula ##STR1## wherein R is alkyl of 1 to 5 carbon atoms, Z is selected from the group consisting of --CH.dbd.CH--, --CH.dbd.CH--CH.dbd.CH-- and (CH.sub.2).sub.n --, n is an integer from 1 to 6 and R.sub.1 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, --NH.sub.4 and alkali metal, alkaline earth metal and aluminum cations and the non-toxic, pharmaceutically acceptable acid addition salts thereof which have antilipolytic activity and are useful intermediates and their preparation and intermediates produced therein.
Claims15
A compound selected from the group consisting of thiazoles of the formula ##STR15## wherein R is alkyl of 1 to 5 carbon atoms, Z is selected from the group consisting of -CH.dbd.CH-, -CH.dbd.CH-CH.dbd.CH- and -(CH.sub.2).sub.n -, n is an integer of 2, 4, or 6 and R.sub.1 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, -NH.sub.4 and alkali metal, alkaline earth metal and aluminum cations and the non-toxic, pharmaceutically acceptable acid addition salts.
Dependencies are inferred from the claim text.