Phthalimidopiperidines and anti-convulsant compositions thereof
AssigneeJohn Wyeth & Brother Limited
InventorsJohn Terence Arnott Boyle, John Christopher Saunders
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Abstract
Phthalimidopiperidines of the formula ##STR1## are described where R.sub.1 is hydrogen, lower alkyl, cycloalkyl of 5 to 7 carbon atoms, phenyl(lower)alkyl, pyridyl(lower)alkyl, furyl(lower)alkyl or thienyl(lower)alkyl and R.sub.2 and R.sub.3 are hydrogen or various substituents. The compounds are useful pharmaceutically, particularly as anti-convulsants, and also in some cases as anti-arrhythmic agents and anti-inflammatory agents, and in some cases useful as intermediates for the preparation of 4-aminoquinoline derivatives having anti-malarial activity.
Claims21
A compound selected from those having the formula ##STR11## and their pharmaceutically acceptable acid addition salts, wherein R.sub.1 is selected from the group consisting of hydrogen, lower alkyl, cycloalkyl of 5 to 7 carbon atoms, phenyl(lower)alkyl, pyridyl(lower)alkyl, furyl(lower)alkyl and thienyl(lower)alkyl, and R.sub.2 and R.sub.3 are independently selected from the group consisting of hydrogen, halogen, lower alkyl, nitro, amino and di(lower alkyl)amino.
A compound selected from those having the formula ##STR12## and their pharmaceutically acceptable acid addition salts, wherein R.sub.1 is selected from lower alkyl and benzyl and R.sub.2 is selected from nitro and amino.
Dependencies are inferred from the claim text.