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US 4,053,613 AGranted
1,3,Thiazolinyl and 1,3 thiazinyl substituted indolinones
AssigneeE. R. Squibb & Sons, Inc.
InventorsGeorge C. Rovnyak, Venkatachala Lakshmi Narayanan, Rudiger D. Haugwitz
Life of this patent
Estimating the term…
Abstract
Indolinone compounds which exhibit anti-inflammatory activity have the following formula ##STR1## wherein R.sup.1, R.sup.3, R.sup.4, R.sup.5, and n are as defined herein.
Claims16
A compound having the formula ##STR59## wherein R.sup.2 is hydrogen, and the radical ##STR60## represents a 5- or 6-membered ring containing three or four carbons and one double bond;
- and pharmaceutically acceptable acid-addition salts thereof.
A compound having the formula ##STR61## wherein R.sup.2 is selected from the group consisting of hydrogen, lower alkyl, phenyl or lower alkylphenyl;
- R.sup.3 is selected from the group consisting of hydrogen, lower alkyl, trifluoromethyl, halo, lower alkoxy, nitro, cyano, amino, di-lower alkylamino or ##STR62## wherein R contains less than 11 carbons and is selected from the group consisting of lower alkyl, lower alkenyl, phenyl, phenyl-lower alkyl, cycloakyl, cycloalkenyl, cycloalkyl-lower alkyl, and cyclo-lower alkenyl, however where n is 2, and adjacent R.sup.3 groups are present, at least one of the R.sup.3 groups is other than t-butyl, trifluoromethyl or nitro;
- aryl is phenyl or phenyl mono-substituted with a member selected from the group consisting of halogen, lower alkyl, nitro, trifluoromethyl, and lower alkoxy;
- n is 1 or 2;
- the radical ##STR63## represents a 5- or 6-membered ring having three or four carbons and one double bond;
- and pharmaceutically acceptable acid-addition salts thereof.
2 more elements
Dependencies are inferred from the claim text.