Penicillins and processes for preparing the same
AssigneeTanabe Seiyaku Co., Ltd.
InventorsMitsutaka Kawazu, Mitsuyoshi Wagatsuma, Masahiko Seto, Toshikazu Miyagishima, Totaro Yamaguchi, Satoshi Ohshima
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Abstract
A compound of the formula: ##STR1## wherein R.sup.1 is hydrogen or hydroxy, R.sup.2 is a group of the formula: --CO-CH(NH.sub.2)-CH.sub.2 COR.sup.3 or --COCH.sub.2 -CH(NH.sub.2)-COR.sup.3, and R.sup.3 is selected from the group consisting of hydroxy, lower alkylamino, di-lower alkylamino, lower alkoxy and hydroxy-lower alkylamino, or R.sup.3 is amino when R.sup.2 is hydroxy. Several methods of preparing the compound [I] are also disclosed. The compound [I] and a pharmaceutically acceptable salt thereof are useful as antimicrobial agents.
Claims43
A compound of the formula:
- ##STR13## wherein R.sup.1 is hydrogen or hydroxy, R.sup.2 is a group of the formula:
- --CO-CH(NH.sub.2)--CH.sub.2 COR.sup.3 or --COCH.sub.2 -CH(NH.sub.2)-COR.sup.3, and R.sup.3 is selected from the group consisting of hydroxy, lower alkylamino, di-lower alkylamino, lower alkoxy and hydroxy-lower alkylamino, or R.sup.3 is amino when R.sup.1 is hydroxy, or a pharmaceutically acceptable salt thereof.
6[-D-2-(D-2-amino-3-N-methylcarbamoyl-propionamido)-2-p-hydroxyphenylac etamido]penicillanic acid or a pharmaceutically acceptable salt thereof.
6-[D-2-(D-2-amino-3-N-isopropylcarbamoyl-propionamido)-2-p-hydroxypheny lacetamido]penicillanic acid or a pharmaceutically acceptable salt thereof.
6-[D-2-(D-2-amino-3-N-n-butylcarbamoyl-propionamido)-2-p-hydroxyphenyla cetamido]penicillanic acid or a pharmaceutically acceptable salt thereof.
6-[D-2-(D-2-amino-3-N-n-hexylcarbamoyl-propionamido)-2-p-hydroxyphenyla cetamido]penicillanic acid or a pharmaceutically acceptable salt thereof.
6-[D-2-(DL-2-amino-3-N-methylcarbamoyl-propionamido)-2-phenylacetamido] penicillanic acid or a pharmaceutically acceptable salt thereof.
6-[D-2-(DL-2-amino-3-N-n-butylcarbamoyl-propionamido)-2-phen ylacetamido]penicillanic acid or a pharmaceutically acceptable salt thereof.
6-[D-2-(DL-3-amino-3-hydroxycarbonyl-propionamido)-2-phenylacetamido]pe nicillanic acid or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.