Compositions and methods for the treatment of coccidiosis

A poultry feed having dispersed therein for control of poultry coccidiosis at least 0.005% by weight of a compound having the formula ##STR15## wherein R.sub.1 is hydrogen atom, a halomethyl group or methyl group;

• R.sub.2 is hydrogen atom or an alkyl group of 1-3 carbon atoms;
• R.sub.3 is hydrogen atom, an alkyl group of 1-3 carbon atoms, allyl group, an alkyl group having 2 to 3 carbon atoms and alkoxy of 1 or 2 carbon atoms as a substituent, an alkly group having 1-3 carbon atoms and hydroxy as a substituent, an alkanoyl group of 1-18 carbon atoms, a haloacetyl group, an alkenoyl group of 3-11 carbon atoms, an aromatic acyl group selected from the group consisting of benzoyl, 2,3-dimethoxybenzoyl, 3,4-dimethoxybenzoyl, 3,5-dimethoxybenzoyl, o-, m-, p-toluoyl, o-, m-, p-chlorobenzoyl, o-, m-, p-bromobenzoyl, p-methoxybenzoyl, o-, m-, p-acetylaminobenzoyl, o-, m-, p-cyanobenzoyl, 2-ethoxy-4-acetylaminobenzoyl, 2-ethoxy-4-dimethylaminobenzoyl, 2-methoxy-4-acetylaminobenzoyl, 3,5-dimethylbenzoyl, and 3,4-dimethylbenzoyl, a heterocyclic acyl group selected from the group consisting of 2-furoyl, 2-thenoyl, isonicotinoyl, nicotinoyl, 5-nitronicotinoyl, and 2-methyl-5-nitronicotinoyl, an N-alkylcarbamoyl group of 1-4 carbon atoms in the alkyl moiety or hydroxy group;
• or an inorganic acid addition salt thereof;
• provided that when R.sub.2 is said alkyl group of 1-3 carbon atoms, R.sub.3 is said alkyl group of 1-3 carbon atoms, and provided that the compound of formula (I) is not defined by a methyl group at the 6-position and a --COHN.sub.2 group at the 5-position.

A method of controlling poultry coccidiosis which comprises orally administering to poultry susceptible to coccidiosis an anticoccidial amount of a compound having the formula ##STR20## wherein R.sub.1 is hydrogen atom, a halomethyl group or methyl group;

• R.sub.2 is hydrogen atom or an alkyl group of 1-3 carbon atoms;
• R.sub.3 is hydrogen atom, an alkyl group of 1-3 carbon atoms, allyl group, an alkyl group having 2 or 3 carbon atoms and alkoxy of 1 or 2 carbon atoms as a substituent, an alkyl group having 1-3 carbon atoms and hydroxy as a substituent, an alkanoyl group of 1-18 carbon atoms, a haloacetyl group, an alkenoyl group of 3-11 carbon atoms, an aromatic acyl group selected from the group consisting of benzoyl, 2,3-dimethoxybenzoyl, 3,4-dimethoxybenzoyl, 3,5-dimethoxybenzoyl, o-, m-, p-toluoyl, o-, m-, p-chlorobenzoyl, o-, m-, p-bromobenzoyl, p-methoxybenzoyl, o-, m-, p-acetylaminobenzoyl, o-, m-, p-cyanobenzoyl, 2-ethoxy-4-acetylaminobenzoyl, 2-ethoxy-4dimethylaminobenzoyl 2-methoxy-4-acetylaminobenzoyl, 3,5-dimethylbenzoyl, and 3,4-dimethylbenzoyl, a heterocyclic acyl group selected from the group consisting of 2-furoyl, 2-thenoyl, isonicotinoyl, nicotinoyl, 5-nitronicotinoyl, and 2-methyl-5-nitronicotinoyl, an N-alkylcarbamoyl group of 1-4 carbon atoms in the alkyl moiety or hydroxy group;
• or an inorganic acid addition salt thereof;
• provided that when R.sub.2 is said alkyl group of 1-3 carbon atoms, R.sub.3 is said alkyl group of 1-3 carbon atoms and provided that the compound of formula (I) is not defined by a methyl group at the 6-position and a --CONH.sub.2 group at the 5-position.