Aryloxypyridine for treating hyperglycaemia
AssigneeBeecham Group Limited
InventorsDavid Edward Thorne, Kurt Engel
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AssigneeBeecham Group Limited
InventorsDavid Edward Thorne, Kurt Engel
Estimating the term…
Compounds of the formula ##STR1## wherein Py is a substituted or unsubstituted 2-, 3- or 4-pyridyl, N-oxidized or quaternized pyridyl group; A is a group of the formula -- ALK--0 -- -- O--ALK -- -- ALK--O--Alk -- wherein Alk is straight or branched chain alkylene of 1 to 6 carbon atoms; R.sub.1 is a carboxylic acid group, a group which is converted in the human body to a carboxylic acid group or acyl; R.sub.2, r.sub.3 and R.sub.4 are each hydrogen, a carboxylic acid group, a group which is converted in the human body to a carboxylic acid group, acyl, hydroxy, alkoxy, aralkoxy, aryloxy, an esterified hydroxy group, nitro, halogen or amino; May be formulated into pharmaceutical compositions useful for the treatment of hyperglycaemia by combining said compounds with a pharmaceutically acceptable non-toxic inert diluent or carrier.
A pharmaceutical composition for the treatment of hyperglycaemia in humans in the form of a beverage, foodstuff, tablet, linguet, powder, capsule, slurry, troche, lozenge or syrup or in a form suitable for administration to humans which comprises a blood sugar lowering amount of a compound of the formula ##STR17## or a pharmaceutically-acceptable, non-toxic acid addition salt thereof, wherein Py is 2-, 3- or 4-pyridyl unsubstituted or substituted by lower alkyl;
A method for the treatment of hyperglycaemia in humans, which comprises administering to such human a hypoglycaemically effective amount of 4-carboxyethyl-phenoxy-2'-pyridylmethane or a pharmaceutically acceptable non-toxic acid addition salt thereof.
Dependencies are inferred from the claim text.