Mercaptoalkylpyridine disulfides
AssigneeMerck & Co., Inc.
InventorsTsung-Ying Shen, Howard Jones, Conrad P. Dorn
Life of this patent
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Abstract
Mercaptoalkylpyridines carrying an ethenyl or ethynyl substituent are prepared from known pyridine compounds, principally pyridoxine, by known chemical procedures, and are useful in the treatment of rheumatoid arthritis and related inflammatory diseases.
Claims12
A compound of structural formula:
- ##STR3## or pharmaceutically acceptable salt thereof wherein m is 0 or 1;
- R" is H or C.sub.2-6 alkanoyl;
- A is ##STR4## or -C.dbd.C, where
- R.sup.7 is hydrogen, chloro or fluoro;
- R is C.sub.1-3 alkyl, hydroxy, C.sub.2-6 alkanoyloxy or hydroxy-C.sub.1-3 alkyl;
- R.sup.1 and R.sup.2 are hydrogen or C.sub.1-3 alkyl;
- and
- R.sup.4 is hydrogen, C.sub.1-3 alkyl, phenyl, chloro or fluoro
The compound of formula:
- ##STR6## or pharmaceutically acceptable salt thereof, wherein R.sup.11 is hydrogen or C.sub.2-6 alkanoyl.
An anti-inflammatory composition in unit dosage form comprising an inert carrier and 5 mg. to 5 gm. of a compound of structural formula:
- ##STR7##
A method of treating rheumatoid arthritis which comprises the administration, to a warm-blooded animal or human in need of such treatment, an effective amount of a compound of structural formula:
- ##STR10##
Dependencies are inferred from the claim text.