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US 4,053,605 AGranted
Esterified-2(3-lower-alkyl-amino-propoxy)-3-cyano-pyridines and derivatives
AssigneeMerck & Co., Inc.
InventorJohn J. Baldwin
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Abstract
Novel cyano substituted (3-loweralkylamino-2-acyl-O-propoxy)pyridines, their pharmaceutically acceptable salts and their preparation are disclosed. The pyridines are vasodilators having antihypertensive activity of rapid onset and extended duration and reduced tendency to cause undesirable tachychardia; they are also .beta.-adrenergic blocking agents.
Claims14
A compound having the formula:
- ##STR8## wherein R is C.sub.3 -C.sub.4 branched alkyl
- L is selected from C.sub.1 -C.sub.10 alkyl, phenyl, mono- and disubstituted phenyl wherein said substituents are independently selected from C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy and halo,
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.