Benzylisoquinoline derivatives, and use as anti-arrhythmic drugs
AssigneeAstra Pharmaceutical Products, Inc.
InventorsJohn Leopold Neumeyer, Paul Andre Tenthorey
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Abstract
Compounds of the class of benzylisoquinoline derivatives of the formula ##STR1## wherein R.sup.1 is selected from the group consisting of hydrogen and methyl, and R.sup.2 is selected from the group consisting of methyl, ethyl, n-propyl and isopropyl, and therapeutically acceptable salts thereof, useful as active ingredients of pharmaceutical preparations for the treatment of cardiac arrhythmias.
Claims27
A compound having the formula ##STR18## wherein R.sup.1 is selected from the group consisting of hydrogen and methyl, and R.sup.2 is selected from the group consisting of methyl, ethyl, n-propyl, and isopropyl, and therapeutically acceptable acid addition salts thereof.
A pharmaceutical preparation for the suppression of cardiac arrhythmias comprising as an active ingredient an amount effective for the suppression of cardiac arrhythmias of a compound having the formula ##STR19## wherein R.sup.1 is selected from the group consisting of hydrogen and methyl, and R.sup.2 is selected from the group consisting of methyl, ethyl, n-propyl, and isopropyl, and therapeutically acceptable acid addition salts thereof, in association with a pharmaceutically and therapeutically acceptable carrier.
A process for the suppression of cardiac arrhythmias in mammals comprising administering to the mammal an amount effective for the suppression of cardiac arrhythmias of a compound having the formula ##STR20## wherein R.sup.1 is selected from the group consisting of hydrogen and methyl, and R.sup.2 is selected from the group consisting of methyl, ethyl, n-propyl, and isopropyl, and therapeutically acceptable salts thereof.
Dependencies are inferred from the claim text.