Compositions for treating coccidiosis containing 5-deazariboflavin and its derivatives
AssigneeMerck & Co., Inc.
InventorsDonald W. Graham, Edward F. Rogers, Wallace T. Ashton
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Abstract
5-Deazariboflavin, its phosphate ester and non-toxic salts thereof and its novel bis(loweralkoxymethylene) derivatives have antiprotozoal and antiparasitic activity. They are particularly useful for controlling cecal and/or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with animal sustenance. The compounds are included in compositions useful for the prevention and treatment of coccidiosis in poultry.
Claims11
A composition useful against coccidiosis that comprises a solid nutritive poultry feed having intimately dispersed therein an effective amount of 5-deazariboflavin or a derivative thereof having the structure:
- ##STR4## wherein R.sub.10 is:
- --CH.sub.2 --(CHOH).sub.3 --CH.sub.2 OR.sub.5
- wherein R.sub.5 is H or ##STR5## and non-toxic salts thereof;
- or R.sub.10 is:
- ##STR6## wherein R.sub.11 is an alkyl group containing 1 to 5 carbon atoms.
A poultry feed premix composition that comprises an inert, solid, nutritive poultry feed having dispersed therein from about 0.1% to about 50% by weight of 5-deazariboflavin or a derivative thereof having the structure:
- ##STR7## wherein R.sub.10 is:
- --CH.sub.2 --(CHOH).sub.3 --CH.sub.2 OR.sub.5
- wherein R.sub.5 is H or ##STR8## and non-toxic salts thereof;
- or R.sub.10 is:
- ##STR9## wherein R.sub.11 is an alkyl group containing 1 to 5 carbon atoms.
A composition for treating coccidiosis comprising poultry feedstuff containing an effective amount of 5-deazariboflavin or a derivative thereof having the structure:
- ##STR10## wherein R.sub.10 is:
- --CH.sub.2 --(CHOH).sub.3 --CH.sub.2 OR.sub.5
- wherein R.sub.5 is H or ##STR11## and non-toxic salts thereof;
- or R.sub.10 is:
- ##STR12## wherein R.sub.11 is an alkyl group containing 1 to 5 carbon atoms.
A composition for treating coccidiosis comprising an animal feedstuff having dispersed therein about 0.0005% to 0.05% by weight of 5-deazariboflavin or a derivative thereof having the structure:
- ##STR13## wherein R.sub.10 is:
- --CH.sub.2 --(CHOH).sub.3 --CH.sub.2 OR.sub.5
- wherein R.sub.5 is H or ##STR14## and non-toxic salts thereof;
- or R.sub.10 is:
- ##STR15## wherein R.sub.11 is an alkyl group containing 1 to 5 carbon atoms.
Dependencies are inferred from the claim text.