Tricyclic 1,2,4-triazolo-quinazolines
AssigneeSandoz Ltd.
InventorsGoetz E. Hardtmann, Faizulla G. Kathawala
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AssigneeSandoz Ltd.
InventorsGoetz E. Hardtmann, Faizulla G. Kathawala
Estimating the term…
The invention discloses 5-substituted-1,2,4-triazolo[4,3-c]quinazolines and 1,2,4-triazolo[1,5-c]quinazolines having pharmacological activity in animals and useful, for example, as hypotensive and anti-inflammatory agents. The compounds may be prepared, for example, by reacting a 5-halo-1,2,4-triazolo-quinazoline with a compound representing the function to be introduced at the 5-position. The 5-halo-1,2,4-triazolo[4,3-c]quinazolines also have pharmacological activity, e.g., hypotensive and anti-inflammatory activity, and may be prepared by reacting a 4-hydrazino-quinazoline with trimethoxy methane. The 5-halo-1,2,4-triazolo[1,5-c]quinazolines also have hypotensive and anti-inflammatory activity and are prepared from the corresponding 1,2,4-triazolo-[1,5-c]quinazolin-5(1H)-one using phosphorus oxychloride, the quinazolin-5(1H)-one being in turn prepared from the 5-halo-1,2,4-triazolo[4,3-c]quinazoline.
A compound of the formula ##STR25## wherein Q and R.sub.a are different and either a nitrogen atom or a =CR'"-function,
Dependencies are inferred from the claim text.