Indanpentol derivatives
AssigneeE. R. Squibb & Sons, Inc.
InventorsFrederic Peter Hauck, Joyce Reid, Venkatachala L. Narayanan, Christopher M. Cimarusti, Rudiger D. Haugwitz, Joseph E. Sundeen
Life of this patent
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Abstract
Compounds are provided having the structure ##STR1## wherein n is 1, 2 or 3, m is 0, 1 or 2, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 may be the same or different and can be hydrogen, lower alkyl, halo-lower alkyl, acyl, lower alkoxy-carbonyl ##STR2## amido ##STR3## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR4## These compounds are useful in the treatment of hypertension.
Claims18
A compound of the structure ##STR201## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are the same or different and are selected from the group consisting of hydrogen, lower alkyl, trifluoromethyl, mono-halo-lower alkyl wherein the halogen is F, Cl, Br or I, acyl radical of a hydrocarbon carboxylic acid of less than 12 carbon atoms, amido, lower alkoxyalkylene and lower alkoxy carbonyl, X is a single bond or a straight or branched chain alkylene group of the structure (CH.sub.2).sub.n' wherein n' is 0 to 10, Y is ##STR202## wherein R.sub.7 and R.sub.8 are the same or different and are selected from the group consisting of hydrogen, lower alkyl, trifluoromethyl, monocyclic cycloalkyl having 3 to 6 ring members, monocyclic cycloalkyl lower alkyl, wherein the cycloalkyl has 3 to 6 ring members, hydroxy-lower alkyl, phenyl, lower alkylphenyl, acyl radical of a hydrocarbon carboxylic acid of less than 12 carbon atoms, di(lower alkyl)phenyl, halophenyl, mono-, di- or tri-nitrophenyl, phenyl lower alkyl, monocyclic heterocyclic, wherein lower alkyl contains 1 to 8 carbons, R.sub.6 is lower alkyl or cycloalkyl having 3 to 6 ring members, and ##STR203## can be taken together to form a heterocyclic radical;
- wherein the heterocyclic radicals represented by R.sub.7, R.sub.8 or ##STR204## taken together contain 5-, 6- or 7-members in the heterocyclic ring, the ring being pyrrolidine, piperidine, morpholine, thiamorpholine, piperazine or homopiperazine provided that one of said rings is always present, and n is 1 to 3;
- m is 0, 1 or 2;
- stereoisomers thereof, physiologically acceptable acid salts thereof, physiologically acceptable quaternary salts thereof and N-oxides thereof.
Dependencies are inferred from the claim text.