Immunological preparations
AssigneeNational Research Development Corporation
InventorsAnthony Clifford Allison, Gregory Gregoriadis
Life of this patent
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Abstract
Immunological preparations are described in which liposomes having a negative charge are used as adjuvants for the purposes of human and veterinary vaccines containing viral or bacterial antigens. The formulation of influenza antigen, and diphtheria and tetanus toxoid antigens in liposomes formed with egg lecithin is described and the adjuvant effect demonstrated.
Claims16
A pharmaceutical preparation for administration in vivo to effect immunization comprising an immunologically effective agent selected from bacterial toxoids which agent is incorporated essentially entrapped liposomes, said liposomes having a negative charge.
A method for the immunization of humans and animals against bacterial infections which comprises administering to such humans and animals an immunologically effective agent selected from bacterial toxoids which agent is incorporated essentially entrapped in liposomes, said liposomes having a negative charge.
A pharmaceutical method which comprises mixing a bacterial toxoid with a lipid and a substance capable of imparting a negative charge, sonicating this mixture to produce liposomes having a negative charge with which said bacterial toxoid is incorporated essentially entrapped, and administering said liposomes to a human or animal to effect immunization thereof.
In the art of parenterally administering bacterial toxoids to patients susceptible to immunization therewith, the improvement which comprises administering such toxoids entrapped essentially in negatively charged liposomes to enhance the immune response thereto.
Dependencies are inferred from the claim text.