Attenuated fowl pox virus preparation for the treatment of infectious diseases, method for the manufacture thereof, and its use
OwnerHelmut Anton Sticklinventor
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Abstract
Preparation for the treatment of interferon-sensitive infectious diseases for use in human and veterinary medicine, characterized by the fact that it contains as active principle a fowl pox virus which has been attenuated by 420 to 800 cell culture passages, optionally together with a pharmaceutical excipient or adjuvant, preferably containing a sufficient number of virus units so as to provide a total of 10.sup.8 to 10.sup.10 virus units per treatment involving 2 to 6 administrations thereof, method for the production thereof, method of producing pharmaceutical forms thereof, the pharmaceutical forms themselves, and a method of growing an effective fowl pox virus for use in the preparations of the invention.
Claims14
Preparation useful for the treatment of interferonsensitive infectious diseases for use in human and veterinary medicine, characterized by the fact that it contains as active principle an effective amount of fowl pox virus, which has been attenuated by 420 to 800 cell culture passages, together with a pharmaceutical excipient or adjuvant.
A method of producing a preparation useful for the endogenic treatment of interferon-sensitive infectious diseases for use in human and veterinary medicine, characterized by (1) applying an original fowl pox virus to a cell culture of embryonated fowl eggs, (2) attenuating it by about 420 to 800 cell culture passages, (3) harvesting the medium with the remaining cells, (4) digesting the cells, (5) separating the coarse cell components from the virus, and (6) recovering the virus from the virus-containing supernatant material by centrifuging, precipitation, or freezedrying.
Dependencies are inferred from the claim text.