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AssigneeSnam Progetti S.p.A.
InventorsMatteo Giongo, Walter Marconi, Nicola Palladino, Francesco Di Gregorio
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A prochiral or racemic substrate such as a prochiral ketone is converted into an optically active product through a process wherein said substrate is subjected to an asymmetric hydrogen transfer reaction by means of an optically active amino-alane or polyimino-alane represented by the formula H.sub.2 AlNR.sub.1 R.sub.2, H Al(NR.sub.1 R.sub.2).sub.2 or (H AlNR).sub.n wherein R, R.sub.1 and R.sub.2 are alkyl, aryl or cycloalkyl radicals, n is an integer higher than 4, and which contains an Al -- N direct bond and an Al -- H bond per aluminum atom, and the third substituent bound to aluminum is halogen, --H, ##STR1## or --OR wherein R has the aforesaid meaning, and wherein the asymmetry center is constituted by a primary or secondary amine group containing an optically active alkyl radical.
A process for asymmetrically hydrogenating acetophenone to an optically active product which comprises contacting acetophenone with N-methyl phenethylamino-alane in the presence of an organic solvent at a temperature in the range of from -100.degree. to +150.degree. C. and thereafter subjecting the reaction mixture to hydrolysis to obtain the optically active product.
A process for asymetrically hydrogenating acetophonone to an optically active product which comprises contacting acetophenone with (+) pipecolino-alane in an organic solvent at a temperature in the range of from -100.degree. to +150.degree. C. and thereafter subjecting the reaction mixture to hydrolysis to obtain the optically active product.
A process for asymetrically hydrogenating acetophenone which comprises contacting acetophenone with poly ( (-) phenethyl) imino alane in an organic solvent at a temperature in the range of from -100.degree. to +150.degree. C. and thereafter subjecting the reaction mixture to hydrolysis to obtain the optically active product.
Dependencies are inferred from the claim text.