Tricyclic prostaglandin intermediates
AssigneeThe Upjohn Company
InventorDouglas R. Morton, Jr.
Life of this patent
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Abstract
Process for preparing bicyclic diols of the formula ##STR1## wherein C.sub.p H.sub.2p is a valence bond or alkylene of one to 4 carbon atoms, inclusive, with one or 2 carbon atoms in the chain between the phenylene ring and --O--; wherein Y is a hydrocarbyl or substituted hydrocarbly group; and wherein indicates attachment to the cyclopropane ring in exo or endo configuration. These diols and the intermediates prepared herein are useful intermediates in preparing prostaglandin analogs having pharmacological utility.
Claims2
A process for preparing an optically active compound of the formula ##STR127## or a racemic mixture of that compound and the enantiomer thereof, wherein R.sub.19 is hydrogen or alkyl of one to 4 carbon atoms, inclusive;
- wherein R.sub.5 and R.sub.6 taken together are --CH.sub.2 -C(CH.sub.3).sub.2 -CH.sub.2 --;
- and wherein indicates attachment to the cyclopropane ring in endo or exo configuration, which comprises reacting an optically active compound of the formula ##STR128## or a racemic mixture of that compound and the enantiomer thereof, wherein , R.sub.5 and R.sub.6 are as defined above, with a compound of the formula ##STR129## wherein R.sub.19 is as defined above.
An optically active compound of the formula ##STR130## or a racemic mixture of that compound and the enantiomer thereof, wherein R.sub.19 is hydrogen or alkyl of one to 4 carbon atoms, inclusive;
- wherein R.sub.5 and R.sub.6 taken together are --CH.sub.2 -C(CH.sub.3).sub.2 -CH.sub.2 --;
- and wherein indicates attachment to the cyclopropane ring in endo or exo configuration.
Dependencies are inferred from the claim text.