N-[2-(Pyridinyl)-4-pyrimidinyl]ureas preparation
AssigneeSterling Drug Inc.
InventorsGeorge Y. Lesher, Baldev Singh
Life of this patent
Estimating the term…
Abstract
N--R.sub.3 --N--R.sub.4 --N'--(2--Q--5--R.sub.1 --6--R.sub.2 --4-Pyrimidinyl)ureas which are useful as anti-allergic agents are prepared by reacting a 2--Q--4--RNH--5--R.sub.1 --6--R.sub.2 -pyrimidine with an R.sub.4 '-isocyanate and reacting the intermediate product with 1,1'-carbonyldiimidasole.
Claims3
The process for preparing a compound of the formula ##STR7## where Q is 4- or 3- or 2-pyridinyl or 4- or 3- or 2-pyridinyl having one or two lower-alkyl substituents or N-oxide thereof, R is hydrogen or lower-alkyl, R.sub.1 is hydrogen, lower-alkyl or cyano, R.sub.2 is hydrogen or lower-alkyl, R.sub.3 is hydrogen, lower-alkyl or lower-hydroxyalkyl, R.sub.4 is hydrogen, lower-alkyl, lower-hydroxyalkyl, lower-alkenyl or lower-cycloalky, which comprises reacting a 2--Q--4--RNH--5--R.sub.1 --6--R.sub.2 -pyrimidine with 1,1'-carbonyldiimidazole to produce N-- (2--Q--5--R.sub.1 --6--R.sub.2 --4--pyrimidinyl)-N-R-imidazole-1-carboxamide and then reacting said 1-carboxamide with R.sub.3 R.sub.4 NH to produce a compound of the formula ##STR8## where R.sub.3 and R.sub.4 have the meanings given above.
Dependencies are inferred from the claim text.