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US 4,053,471 AGranted
4-Thiazolidinone derivatives
AssigneeE. R. Squibb & Sons, Inc.
InventorJohn Krapcho
Life of this patent
Estimating the term…
Abstract
Compounds having the formula ##STR1## wherein R.sub.1 is alkyl, cycloalkyl or aryl; R.sub.2 is alkylamino, dialkylamino or a nitrogen containing heterocyclic group; A.sub.1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A.sub.2 is an alkylene group having 2 to 5 carbon atoms; have anti-inflammatory activity.
Claims11
A compound having the formula ##STR6## or a pharmaceutically acceptable salt thereof, wherein R.sub.1 is alkyl, cycloalkyl or aryl;
- R.sub.2 is alkylamino, dialkylamino, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 1-piperazinyl, or 4-alkyl-1-piperazinyl;
- A.sub.1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms;
- and A.sub.2 is an alkylene group having 2 to 5 carbon atoms;
- wherein the term aryl refers to phenyl or phenyl substituted with a halogen, alkyl, alkoxy, trifluoromethyl, nitro or amino group;
- alkyl and alkoxy refer to groups having 1 to 6 carbon atoms;
- and cycloalkyl refers to a group having 3 to 7 carbon atoms.
3 more elements
Dependencies are inferred from the claim text.