Antibody specific to methaqualone and its metabolites
AssigneeHoffmann-La Roche Inc.
InventorJames Gordon Christenson
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Abstract
A sensitive radioimmunoassay for methaqualone and its major metabolites is described. Included within this disclosure is the preparation of novel methaqualone haptens, the preparation of antigens from such haptens by coupling to an immunogenic carrier material, the use of such antigens to elicit antibodies selective to methaqualone and its major metabolites and an improved radiolabelled derivative of a methaqualone analog used in the practice of said radioimmunoassay.
Claims3
An antibody specific to methaqualone and its metabolites prepared by innoculating a host animal with an antigen consisting essentially of a methaqualone hapten having a methaqualone radical bonded to a spacing group through the tolyl ring of said methaqualone radical, said spacing group being selected from the group consisting of an amino carbonylalkylene carboxy, an oxyloweralkylene carboxy and a lower alkylenecarboxy group and having from 2 to 7 carbon atoms in the linking chain, said hapten being covalently bonded to an immunogenic carrier material through the carboxyl group of said spacing group.
Dependencies are inferred from the claim text.