Oxopyridazinylthiomethyl derivatives of ureidocephalosporins
AssigneeE. R. Squibb & Sons, Inc.
InventorsHermann Breuer, Uwe D. Treuner
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Abstract
Ureido cephalosporin derivatives of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion, or the group ##STR2## R.sub.1 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl or phenyl-lower alkyl, or certain heterocyclic groups; R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen or methoxy; R.sub.4 is hydrogen, halogen, lower alkyl, or lower alkoxy; R.sub.5 is hydrogen or lower alkyl; R.sub.6 is lower alkyl, phenyl, or phenyl-lower alkyl; are disclosed. These compounds are useful as anti-bacterial agents.
Claims12
A compound of the formula ##STR76## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion, or ##STR77## R.sub.1 is phenyl, phenyl-lower alkyl, substituted phenyl, or substituted phenyl-lower alkyl wherein said substituent is one to three members selected from the group consisting of halogen, lower alkyl, lower alkoxy, and hydroxy;
- R.sub.2 is hydrogen or lower alkyl;
- R.sub.4 is hydrogen, halogen, lower alkyl of 1 to 4 carbons, or lower alkoxy of 1 to 4 carbons;
- R.sub.5 is hydrogen or lower alkyl;
- and R.sub.6 is lower alkyl, phenyl, or phenyl-lower alkyl.
Dependencies are inferred from the claim text.