Thromboxane B analogs

A thromboxane alanog of the formula ##STR158## wherein Z.sub.5 is ##STR159## or ##STR160## wherein g is 1, 2, or 3;

• wherein X.sub.1 is
• 1. --CH.sub.2 OH, or
• 2. --COOR.sub.1, wherein R.sub.1 is alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, phenyl substituted with one or two chloro, fluoro, or alkyl of one to 4 carbon atoms, inclusive, or a pharmacologically acceptable cation;
• wherein R.sub.6 is hydrogen or alkyl of one to 4 carbon atoms, inclusive;
• wherein Y.sub.1 is trans--CH.dbd.CH-- or --CH.sub.2 CH.sub.2 --;
• wherein M.sub.1 is ##STR161## or ##STR162## wherein R.sub.5 is hydrogen or methyl;
• wherein L.sub.1 is ##STR163## or a mixture of ##STR164## and ##STR165## wherein R.sub.3 and R.sub.4 are hydrogen, methyl, or fluoro, being the same or different with the proviso that one of R.sub.3 and R.sub.4 is methyl only when the other is hydrogen or methyl;
• wherein R.sub.7 is
• 1. --(CH.sub.2).sub.m --CH.sub.3, ##STR166## or ##STR167## wherein l is 0, 1, 2, or 3, wherein m is 1 to 5, inclusive, T is alkyl of 1 to 3 carbon atoms, inclusive, alkoxy of one to 3 carbon atoms, inclusive, chloro, fluoro, or trifluoromethyl, and s is 1, 2, or 3, the various T's being the same or different, with the proviso that not more tha two T'S are other than alkyl, with the further proviso that R.sub.7 is ##STR168## only when R.sub.3 and R.sub.4 are hydrogen or methyl, being the same or different.