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US 4,052,514 AGranted
Trihalosubstituted biphenylyl propionic acids
AssigneeThe Boots Company PLC
InventorsStewart S. Adams, Bernard J. Armitage, John S. Nicholson
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Abstract
Novel trihalosubstituted biphenylyl propionic and acetic acids and their derivatives are described together with processes for their preparation and composition of them. They are useful as anti-inflammatory agents.
Claims20
A compound selected from the group consisting of acids having the general formula:
- ##STR28## in which R.sub.1, R.sub.2 and R.sub.3 are individually selected from chlorine, bromine and fluorine and Y is COOH, or a pharmaceutically acceptable lower-alkyl ester, in an alkali metal salt, or an amine salt thereof.
2-(2,2',4'-Trifluoro-4-biphenylyl)propionic acid.
2-(2-Chloro-2',4'-difluoro-4-biphenylyl)propionic acid.
2-(2'-Chloro-2,4'-difluoro-4-biphenylyl)propionic acid.
2-(4'-Chloro-2,2'-difluoro-4-biphenylyl)propionic acid.
Dependencies are inferred from the claim text.